Since tumor vasculature is important for T cell infiltration, and CD8+ T cells are critical for the antitumor effect of STING agonist (Figure 1G), we next analyzed T cell infiltration in tumors,and found that there was a decrease in intratumoral CD3+ T cell and CD8+ T cell infiltration in Stingfl/fl/Cdh5-Cre mice upon intratumor DMXAA treatment, compared with that of WT mice (Figure 3D and Supplemental Figure 3, A and B). This evidence concerns the gene CD8A and neoplasm.