To explore this possibility, we first generated endothelium-specific Sting KO mice by crossing Tek-Cre or tamoxifen-inducible Cdh5-CreERT2 transgenic mice with Stingfl/fl mice to obtain Stingfl/fl/Tek-Cre and Stingfl/fl/Cdh5-Cre mice (Supplemental Figure 2I), then performed tumor xenograft and treatment experiments using these mice. Here, CDH5 is linked to neoplasm.