CDH5 and neoplasm: Compared with that of WT mice that received STING agonist treatment, we found that IFN-β induction was significantly reduced in tumor tissues from Stingfl/fl/Cdh5-Cre mice and was even lower in tumor tissues from Stingfl/fl/LysM-Cre and Stingfl/fl/Itgax-Cre mice, indicating that all these cell types produced IFN-β upon STING activation, but none of these cKO mice completely lost IFN-β induction (Figure 3E).