Together with our data that SepSecS-specific B cells are found only in patients who are anti-SLA positive while SepSecS-specific CD4+ T cells are present in patients with AIH irrespective of anti-SLA status and also in individuals in the control groups, these findings highlight a key pathophysiological role for B cells in AIH, offering a rationale for the design of improved, targeted therapies to treat AIH. Here, SLA is linked to autoimmune hepatitis.