Centrum TMD was significantly higher, and to a similar extent, in crispants for daam2 (p<0.05; z=1.54), esr1 (p<0.05; z=1.62), and sost (p<0.05; z=1.41), three genes likely involved in osteoporosis pathogenesis. The gene discussed is DAAM2; the disease is osteoporosis.