This patient presented with a negative QuantiFERON-TB result in the setting of advanced AIDS with an initial low CD4 count of 25 cells/μL (3.2%) and impaired CD4 cell function, reflected by inversion of the CD4:CD8 ratio on fine-needle tissue biopsy of the pancreatic mass despite a CD4 count >200 cells/μL and viral load suppression [10, 11]. Here, CD8A is linked to AIDS.