Aged C57BL/6J mice (18–32 monthsold) are widely used to model age-related loss of muscle mass andfunction, termed sarcopenia, as they replicate the biochemical andphysiological features of muscle aging in humans, providing an idealmodel for testing therapeutic interventions.13,15 Aged 18 month mice were treated with either ALT-007 (1 mg/kg) orDMSO mixed in the food. This evidence concerns the gene GPT and sarcopenia.