In contrast, the overexpression of the KAT7-G485A mutant did not affect MRAS expression, H3K14 acetylation, phosphorylation of ERK1/2 (Figure 7B-C), cell proliferation (Figure 7D-F), or apoptosis (Figure 7G-I) in KAT7 knockdown CRC cells. This evidence concerns the gene MRAS and colorectal carcinoma.