GSDME and autosomal dominant nonsyndromic hearing loss: Previous studies have shown that certain chemotherapy drugs, like 5-FU, induce pyroptosis mediated by cleaved gasderminE (GSDME, also called deafness autosomal dominant 5, DFNA5), and the mechanism of cell death can shift from apoptosis to pyroptosis depending on the GSDME level 20-22.