EGFR and neoplasm: sEVs-derived from EGFR-overexpressed CAL27 cells (CAL27Hi-EGFR) not only significantly promoted the formation of tube-like structures of vascular endothelial cells (Figure S3D and Figure 1D), but also significantly increased the intra-tumor microvessel density in murine OSCC models, resulting in more rapid tumor growth (Figure 1E-I).