S1PR1 and myocardial infarction: Our previous reports revealed that EC-specific deletion of S1pr1 inhibited the proliferation of reparative F4/80+Ly6clow macrophages, exacerbating pathological cardiac remodeling and worsening cardiac dysfunction following myocardial infarction in mice, demonstrating a key role of EC-expressing S1PR1 for cardiac homeostasis 20.