NLRP3 and ischemia reperfusion injury: In contrast, several researches showed that TRPV1 could suppress the inflammatory reactions and synaptic phagocytosis by inhibiting lipid accumulation of microglia in neurodegenerative diseases 88,89, and could also restrain the NLRP3 activation in microglia by regulating autophagy after ischemia-reperfusion injury 90.