In contrast, several researches showed that TRPV1 could suppress the inflammatory reactions and synaptic phagocytosis by inhibiting lipid accumulation of microglia in neurodegenerative diseases 88,89, and could also restrain the NLRP3 activation in microglia by regulating autophagy after ischemia-reperfusion injury 90. The gene discussed is NLRP3; the disease is neurodegenerative disease.