The significantly upregulated hub genes in the group of high-level BC cell-derived EVs versus normal cell-derived EVs include IL1B, FN1, C-X-C motif chemokine ligand 8 (CXCL8) 45, peroxidasin (PXDN) 46, interleukin 1 alpha (IL1A) 47, and colony stimulating factor 2 (CSF2) 48 (Figure 2H). The gene discussed is CXCL8; the disease is breast cancer.