The SNaPshot technique meets all the necessary conditions for the detection of mutations in the KRAS and NRAS genes in patients with CRC, as it allows to detection of several SNPs in a single reaction decreasing costs and execution times, in addition to is sensitive with low amounts of DNA, even degraded DNA, as it is effective with short length sequences [50-80pb] [5], but the same has never been realised for this type of diagnosis in Venezuela patients. The gene discussed is KRAS; the disease is colorectal carcinoma.