Regarding the analysis of the NRAS gene, a mutation frequency of 15.1% was obtained, quite high in relation to that previously reported both for the Venezuelan population in which this frequency varied between 1.6% and 2.6% of patients, and in other parts of the world where alterations of this gene appeared in approximately 3% or 5% of cases of CRC, and whose meaning should be studied further [27, 28]. This evidence concerns the gene NRAS and colorectal carcinoma.