Th17 is differentiated by TGF-β, IL-6 and other cytokines, the main transcription factor is RORγt (also a TH17-specific molecule), secretes IL-17, IL-21, IL-22, GM-CSF and other cytokines, mainly activates and recruit neutrophils, responsible for clearing extracellular bacterial and fungal infections [81]. This evidence concerns the gene IL21 and fungal infectious disease.