We found 36 immune cells were associated with HCC, CD64 on CD14− CD16+ monocytes (OR = 1.328, 95% CI = 1.116− 1.581, p = 0.001), CD3− lymphocyte %lymphocytes (OR = 1.341, 95% CI = 1.027− 1.750, p = 0.031), HLA DR on CD14+ monocytes (OR = 1.256, 95% CI = 1.089− 1.448, p = 0.002), CD19 on CD19 on Plasma Blast−Plasma Cell (OR = 1.224, 95% CI = 1.073− 1.396, p = 0.003), CCR2 on monocytes (OR = 1.204, 95% CI = 1.073− 1.351, p = 0.002) and Naive CD4+ T cell Absolute Count (OR = 0.797, 95% CI = 0.655− 0.969, p = 0.023) were the most strongly associated with HCC. Here, CD4 is linked to hepatocellular carcinoma.