HK2 and gastric cancer: On this basis, Fang et al. experimentally found that the knockdown of the Circ-SLAMF6 gene suppressed glucose consumption, lactate production and HK2 protein expression in hypoxia-induced GC cells, and the cell migration invasion ability was weakened, indicating that Circ-SLAMF6 promotes glycolysis and invasive migration in hypoxic GC cells [46].