In GC tissues, the expression of HNRNPK protein was significantly upregulated, and experiments showed that when HNRNPK was overexpressed, the ECAR of GC cells was elevated, the OCR was decreased, the glucose uptake rate and lactate production rate of GC cells were elevated, and the glycolysis process was accelerated, and the inhibitory effects of miR-873-5p on the proliferation, invasion, EMT process, and Warburg effect of GC cells were reversed. Here, HNRNPK is linked to gastric cancer.