Li et al. demonstrated experimentally that miR-576-3p directly inhibited HIF-1α expression in GC cells and antagonized the pro-proliferative and metabolic effects of HIF-1α in GC cells, and this antagonistic effect could not be reversed by the overexpression of Circ-DNMT1, while the silence of HIF-1α expression inhibited the promotion of Circ-DNMT1 on GC cell proliferation, migration and glycolysis [42]. Here, DNMT1 is linked to gastric cancer.