In our patient, considering the fact that the presence of symptoms common to the pancreatic involvement of sarcoidosis like jaundice and epigastric pain, elevated serum ACE level with a normal CA 19-9 level, CT evidence of ill-defined hypodense focal lesion in the pancreas in the background of high-resolution CT findings of pulmonary sarcoidosis, and EUS confirmation of the presence of well-formed discrete epithelioid granulomas, it was decided to manage the patient as per pancreatic involvement of systemic sarcoidosis. This evidence concerns the gene ACE and pulmonary sarcoidosis.