NDUFA13 and Leigh syndrome: A study analysing brain transcriptomic data available in the United Kingdom Brain Expression Consortium (UKBEC) network showed that 64% of genes linked to Leigh syndrome are enriched in the substantia nigra, which may explain the predilection for the substantia nigra in NDUFA13 deficiency and other causes of Leigh syndrome.12 Basal ganglia lesions, a frequent finding in Leigh syndrome, were only observed in three individuals with NDUFA13 deficiency.