Tregs frequencies in relation to CD4 lineages are known to be reduced in ALS, and the downregulation of these immune regulators is inversely correlated with the rate of disease progression and directly to length of survival.53 RvD1 has been shown to increase anti-inflammatory Tregs in vitro and to correct the Treg/Th17 imbalance seen in conditions like lupus erythematosus, reducing the differentiation of these cells into a pro-inflammatory (Th17) phenotype, known to produce IL-17, IL-22 and IL-23 and to recruit neutrophils to sites of inflammation.54,55. This evidence concerns the gene CD4 and lupus erythematosus.