Our mononuclear cell clustering and expression analysis of GPR32 and GPR18 showed that these receptors were minimally or not expressed in most B cell subsets, naïve helper T cells and Tregs in pwALS with faster progressing and bulbar onset disease, the same clinical variant of ALS individuals with a low concentration of resolvins in circulation. The gene discussed is GPR18; the disease is amyotrophic lateral sclerosis.