CSF reflecting lower levels of three ‘pro-aging’ factors (CCL2, CCL11 and B2 M) and higher levels of two ‘pro-youthful’ factors (CSF2 and BGLAP) associated with slower cognitive, functional and neuroaxonal declines in adults with autosomal dominant forms of FTD and sporadic Alzheimer’s disease. The gene discussed is CCL2; the disease is frontotemporal dementia.