BGLAP has been shown to decrease in adulthood across species, crosses the BBB, and binds to brain stem (ventral tegmentum area and mid/dorsal raphe) and hippocampal regions.20 Pre-clinical studies suggest BGLAP can promote vesicular transport of brain derived neurotrophic factor, increase monoamine synthesis and inhibit GABA synthesis subsequently promoting learning and memory and preventing anxiety-like behaviours. The gene discussed is BGLAP; the disease is Anxiety.