CSF reflecting lower levels of three ‘pro-aging’ factors (CCL2, CCL11 and B2 M) and higher levels of two ‘pro-youthful’ factors (CSF2 and BGLAP) associated with slower cognitive, functional and neuroaxonal declines in adults with autosomal dominant forms of FTD and sporadic Alzheimer’s disease. Here, BGLAP is linked to frontotemporal dementia.