It is possible that the same mechanisms we predict to be providing beneficial effects in DSS‐induced colitis may result in the failure of A. suum EVs in TNBS‐induced colitis, for example, the EV‐mediated and rapid downregulation of CCR2 likely prevents recruitment of anti‐inflammatory monocytes to the intestine that we have shown were crucial for attenuation of T cell responses. The gene discussed is CCR2; the disease is colitis.