Employing a random‐effects model, the analysis revealed that in tumor tissue samples from GBM patients, OSMR (MD = 1.15, 95% CI = 0.69–1.60), G0S2 (MD = 0.76, 95% CI = 0.24–1.28), IGHG2 (MD = 1.42, 95% CI = 1.14–1.70), and FMOD (MD = 1.48, 95% CI = 0.22–2.74) exhibited significantly higher expression compared to normal control tissue samples. This evidence concerns the gene G0S2 and glioblastoma.