Combining the results of scRNA‐seq analysis, we further confirmed the correlation of OSMR, G0S2, IGFBP6, IGHG2, FMOD, and their risk model with macrophages and other immune infiltrations, providing new theoretical evidence for elucidating the specific mechanisms by which ferroptosis impacts tumor immunity in GBM. This evidence concerns the gene IGHG2 and neoplasm.