Stable over-expression of CMTR1 or ELAVL1 into HGC-27 cells resulted in increase of growth, tumor weight, CD31-positive microvessels, and Ki-67 proliferative index of subcutaneous xenografts formed in nude mice, accompanied by up-regulation of CD44v, which were prevented by knockdown of SNORA37 (Fig. 7d-f and Additional file 1: Fig. S8d, e). The gene discussed is MKI67; the disease is neoplasm.