For example, CMTR1 is able to recruit RNA polymerase II to transcription start site of signal transducer and activator of transcription 3 (STAT3) essential for cancer cell proliferation and anti-tumor immunity, while suppression of CMTR1 significantly boosts the efficacy of programmed death-1 (PD1) blockade by encouraging the infiltration of CD8+ T cells in tumor microenvironment [42]. Here, CD8A is linked to cancer.