Our study revealed increased expression of c-Myc together with high expression of the mesenchymal markers VIM (Vimentin), FN1 (Fibronectin), ZEB2 (SIP-1), FOXC2, SNAIL1 (Snail), SNAIL2 (Slug), and TWIST and the cancer stem-like cell marker CD44 in cells and tumors lacking MCPIP1 RNase activity. The gene discussed is TWIST1; the disease is cancer.