Next, we evaluated the expression of CD44 in tumors consisting of ccRCC cell line Caki-1 and detected higher protein expression of CD44 in tumors containing the MCPIP1 mutation (pLIX D141N) than in control tumors (pLIX PURO) (Fig. 7D). This evidence concerns the gene ZC3H12A and nonpapillary renal cell carcinoma.