IL6 and neoplasm: Our findings suggest that the absence of MCPIP1 in premalignant cells alters the inflammatory microenvironment by promoting increased infiltration of M2 macrophages, as well as the release of VEGF and IL-6, which drive angiogenesis and tumor progression Future studies will be necessary to elucidate the role of MCPIP1 activity in shaping the tumor microenvironment during tumor development, and to further explore the mechanisms by which MCPIP1 expression may facilitate escape from adaptive immunity.