INS and type 2 diabetes mellitus: In Part 2, the patients with T2DM received a sequence of four treatments on separate days: NN1952 at the safe and appropriate dose identified in Part 1, with a 12-h euglycemic glucose clamp; insulin aspart with glucose clamp; NN1952 15 min before meals; and oral placebo 15 min before meals; with washout periods between each visit day, to minimize carry-over effects.