PCSK9 and familial hyperaldosteronism: It is currently believed that LDL levels are closely related to the genotype and the type of mutation: HeFH < double heterozygote < homozygous APOB or PCSK9 mutation < homozygous LDLRAP1 or LDLR-defective mutations < compound heterozygote LDLR-defective + LDLR-negative mutations < homozygous LDLR-negative mutations. In some patients, although genetic testing results indicated HeFH or cHeFH or double-heterozygous FH, these patients were diagnosed with HoFH in clinical [1, 10].