LDLR and atherosclerosis: This condition is characterized by polymorphisms in the low-density lipoprotein receptor (LDLR) gene and a resultant elevation in serum LDL levels. In HoFH, defects in the typical LDL receptor pathway lead to reduced clearance of LDL, thereby increasing plasma LDL concentrations along with TC levels, eventually leading to valvular heart disease strokes and even the potential for fatal early atherosclerotic cardiovascular disease (ASCVD) [1].