While ALDH2 has been reported to be involved in monoamine metabolism in the liver [20] and alcohol metabolism in the brain [21], our NGS data reported upregulation of Aldh1a1 in Aβ-treated AD-like astrocytes (Fig. 1), suggesting the involvement of ALDH-family members other than ALDH2 in this process. This evidence concerns the gene ALDH2 and Alzheimer disease.