In order to determine the role of SIRT2 in aberrant GABA production in AD, we performed astrocytic knockdown experiments in APP/PS1 animals by injecting lentiviruses carrying pSico-Scr/shSIRT2-eGFP each and AAV-GFAP-Cre-mCherry virus in the hippocampal DG (Fig. 6F, Fig. S2). The gene discussed is APP; the disease is Alzheimer disease.