Notably, a loss of function of TDP-43, including the regulation of axonal [47] and dendritic [43, 48] transport of mRNAs in neurons, would lead to the development of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), etc. [40, 49–51]. Here, TARDBP is linked to amyotrophic lateral sclerosis.