In an animal study on sepsis rabbits, Wang et al. [30] found that ONSD was significantly wider in the SAE group than the control group, and ONSD changes were positively correlated with the brain injury biomarkers, including S100B, neuro-specific enolase (NSE), and myeloperoxidase (MPO), at 6, 12, and 24 h, respectively. This evidence concerns the gene S100B and Sepsis.