AUTS2 and microcephaly: Nevertheless, our Auts2 cKO mice (Emx1Cre/+; Auts2fl(ex8)/fl(ex8) or Auts2fl(ex8)/+) may recapitulate at least some of the pathophysiology of microcephaly in human AUTS2 syndrome, since we observed a decrease in dividing IPCs and a decrease in the number of upper-layer neurons and thickness of the cerebral cortex.