AUTS2 and microcephaly: Since the functional changes in the AUTS2T534P protein differ from those in our mouse model (Emx1Cre/+; Auts2fl(ex8)/fl(ex8)), in which expression of FL-AUTS2 and S-AUTS2-var.1 is lost and that of S-AUTS2-var.2 is increased (Appendix Fig. S1B), the microcephaly phenotype may be expressed through slightly different mechanisms in each pathological model.