TSC2 and autosomal dominant polycystic kidney disease: Blood pressure treatment targets should also be lower in children with TSC2–PKD1 contiguous gene deletion who are on medical management for hypertension, as this may have a renoprotective effect and help to preserve GFR based on studies of other cystic kidney diseases such as autosomal dominant polycystic kidney disease (ADPKD) [15, 16].