Other pathways highlighted were the KEGG ‘vascular smooth muscle contraction’ pathway (N genes in gene set = 115; N genes = 24; adjusted-P = 5.18 × 10− 3) and ‘gonadotropin-releasing hormone (GNRH) signalling’ pathway (N genes in gene set = 101; N genes present = 22; adjusted-P = 5.18 × 10− 3) in the Alzheimer’s disease PRS, and the GO ‘membrane repolarization’ pathway (N genes = 43; beta[SE] = 1.25[0.06]; adjusted-P = 4.45 × 10− 13), in the AF PRS. Here, GNRH1 is linked to Alzheimer disease.