We could show that wildtype (wt) HSV-1 infection as well as infection with HSV-1-Δ γ34.5 resulted in DUX4 protein expression, whereas DUX4 expression is abrogated in cells infected with HSV-1 lacking either ICP0 (expressing ICP4-YFP protein) or ICP4 (Fig. 2C and Fig. S3C). The gene discussed is DUX4; the disease is infection.