HIF1A and glioblastoma: Previous studies have shown that Roxadustat-induced stabilization of Hif1α suppresses chemoresistant glioblastoma growth by inducing ferroptosis.48 Increased Hif1α expression has been consistently associated with the promotion of ferroptosis in various diseases.49,50 Hif1α expression was reported as a key regulator involved in hypoxic apoptosis of MLO-Y4 osteocytes51 and it also plays a complex role in bone biology, exhibiting both protective and inhibitory actions under different conditions.