In particular, melanoma-induced osteocyte ferroptosis is specifically dependent on Hmox1, a known factor in heme oxidation and iron metabolism important for ferroptosis.35–37 By specifically targeting Hmox1 with the Znpp inhibitor or shRNA, our results clearly confirm its critical regulatory role both in vivo and in vitro and firmly link it to the regulation of ferroptosis. The gene discussed is HMOX1; the disease is melanoma.