HIF1A and osteoporosis: For instance, stabilizing Hif1α isoforms causes high bone mass phenotypes during bone development.52 Conversely, in some pathological conditions, Hif1α activation enhances osteoclast-mediated bone resorption, resulting in bone loss.53 Hif1α plays also a dual role in senile osteoporosis.54 These findings underscore Hif1α‘s complex role in different disease contexts.