This seems contradictory to the former, on the one hand probably because mast cells release VEGF, histamine, etc. To promote the development of inflammation as well as tumor angiogenesis thus showing promotion of tumor development; On the other hand, the tumor microenvironment also harbors immune cells, such as CD8+ T cells and NK cells, which collaborate with mast cells to suppress tumor development. This evidence concerns the gene VEGFA and neoplasm.