Aside from lysosomal biogenesis and autophagy, TFEB has been studied in the context of angiogenesis (Doronzo et al, 2019), immune response (Nabar & Kehrl, 2017), epithelial–mesenchymal transition (Huan et al, 2005; Li et al, 2020), and cancer metabolism (Di Malta & Ballabio, 2017), among other processes in various disease-related models. The gene discussed is TFEB; the disease is cancer.