For example, 11 of the 32 patient sera immunoprecipitatedRo52/TRIM21 (tripartite motif-containing protein 21) (Figure 2G), a known autoantigen inSjögren’s syndrome, systemic lupus erythematosus, andother rheumatic autoimmune diseases.34−39. The gene discussed is TRIM21; the disease is systemic lupus erythematosus.