The ABHD5–PNPLA3 interaction is important for metabolic health, as a common genetic variant of PNPLA3 (rs738409; minor allele frequency ∼ 35% (7)), I148M, is the most prevalent genetic risk factor for the development of MASLD (8, 9). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.