In addition to interfering with tau phosphorylation, Aβ interferes with tau oligomerization and aggregation, increasing neuronal damage through the activation of CDK-5- and GSK-3β-mediated tau oligomer formation, which, in turn, leads to neurodegeneration.65Therefore, lipid metabolic disorders may affect the activity of these kinases, ultimately affecting tau hyperphosphorylation. This evidence concerns the gene MAPT and Disorder of lipid metabolism.