MAPT and tauopathy: Indeed, lipid rafts contain a pool of hyperphosphorylated tau, indicating that cholesterol may modulate tauopathies.62Moreover, Aβ accelerates the phosphorylation of tau proteins by mediating tau phosphorylation-related kinases such as cell cyclin-dependent kinase 5 (CDK5) activator 1 and glycogen synthase kinase 3β (GSK3β).