IFNA1 and tuberculosis: Multiple genes up-regulated in both conditions have previously been demonstrated to play key roles in tuberculosis disease [Apoe (49)], immune evasion [Trem2 (50)], inhibition of autophagosome formation [Coro1a (51)], biomarker discovery [C1q (52, 53)], and general IFN-induced or inflammasome induction (Itm2b and Ucp2).