A variety of immune phenotypes have been described in typical EV patients, including reduced responses to DNCB sensitization and T cell proliferation in response to non-specific mitogens [54, 56–59], increased NK cell activity [60], normal antibody-dependent cellular cytotoxicity [61], no association of EV with particular HLA antigens [62], decreased numbers of CD4+ T cells and CD8+ T cells, but normal T suppressor cell numbers [61]. The gene discussed is CD4; the disease is epidermodysplasia verruciformis.