AQP5 and obesity due to melanocortin 4 receptor deficiency: At the FAIM2 locus on chr 12q13.12, we observed known genes associated with obesity, eating patterns, and diabetes-related traits, including ASIC1, AQP2, AQP5, AQP6, RACGAP1, and AC025154.2 (AQP5-AS1) along with FAIM2 (Table 1).