Indeed, missense mutations have been previously reported for this gene in the context of obesity (Grarup et al., 2018; Stergiakouli et al., 2014) while another member of this gene family, ADCY5, has also been extensively implicated in metabolic traits (Sinnott-Armstrong et al., 2021). This evidence concerns the gene ADCY5 and obesity due to melanocortin 4 receptor deficiency.