SH3YL1 and obesity due to melanocortin 4 receptor deficiency: At the TMEM18 locus on chr 2p25.3, a highly significant human obesity locus that has long been associated with both adult and childhood obesity, we observed differing degrees of evidence for 16 genes, but noted that rs6548240, rs35796073, and rs35142762 consistently contacted the SH3YL1, ACP1, and ALKAL2 promoters across multiple cell types (Figure 2C -third and fourth column).