DSG2 is a calcium‐binding single‐pass transmembrane glycoprotein of the cadherin protein family known to mediate cell‐cell adhesion through dimerization via its extracellular domains.[39, 40] There is increasing evidence indicating that DSG2 plays a crucial role in cancer cell proliferation and tumor progression.[41, 42, 43, 44] In addition, DSG2 has been reported to be overexpressed in a large fraction of melanomas and be correlated with poor clinical outcomes. This evidence concerns the gene CDH17 and cancer.