MAPT and Alzheimer disease: SAMP8 mice exhibit other classical features of AD such as Tau hyperphosphorylation, with several studies showing increased levels of various phosphorylated Tau (pTau) species in SAMP8, including pThr231,3,24 pSer214,3 pSer396, and pSer199.24 Moreover, SAMP8 mice also show increased pTau immunoreactivity in neuronal cell bodies.3,21,24,25 Despite this, characterization of these Tau aggregates is still lacking.