LGALS3 and Alzheimer disease: In mouse AD models, Gal-3 is localized to Aβ-plaques, specifically in Aβ-plaque-associated microglia.86,87 The involvement of Gal-3 in AD is further bolstered by SNPs found in the LGALS3 gene which increase the risk of developing AD.86 Gal-3 is a druggable target with small molecule inhibitors in clinical trials for inflammatory diseases and AD.