Galectins function as inflammation regulators and Gal-3 has emerged as an important potentially upstream regulator of AD.80 While all members of the galectin family have a c-terminal carbohydrate recognition domain (CRD), Galectin-3 (Gal-3) is the only chimeric member of the family; its n-terminal protein-binding domain allows it to oligomerize with other Gal-3 molecules.81 We previously reviewed Gal-3 and its role in neurogenesis and neurological conditions, including AD.80 This evidence concerns the gene LGALS3 and Alzheimer disease.