Using BrdU (a marker of the S-phase of the cell cycle) with SOX2, GFAP, DCX, and NeuN, Diaz-Moreno et al showed that although early progenitors are unaffected, the maturing DCX+ neuroblast population is significantly reduced in SAMP8 mice.50 In line with this, hippocampal LTP is significantly compromised in SAMP8 mice.78 Another study examined changes in neurogenesis of SAMP8 mice at 5 and 10 months.7 However the study of SAMP8 at 5 months is after they start showing cognitive defects (16W). This evidence concerns the gene DCX and Cognitive impairment.