With the exception of one study linking these changes to CSF phosphorylated tau (p-tau) levels, white matter integrity, entorhinal cortex thickness and memory abilities in early Alzheimer's disease,29 comprehensive evaluations relating functional connectivity within the AT and PM networks to markers of pathological and clinical severity across the Alzheimer's continuum are lacking. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.