MAPT and Cognitive impairment: The excitatory/inhibitory imbalance caused by amyloid deposition might trigger hyperconnectivity within the AT network,84-90 potentially accelerating the spread of tau to PM regions via entorhinal-mediated connections.57,91-94 Induced neuronal toxicity would lead to hypometabolism and neurodegeneration,25,76,95 ultimately resulting in cognitive impairment.