The only other listed association for GCC2 is for a homozygous missense variant, R1669H, present in a patient with a severe neurological disease, although it was not clear if there was any immunological phenotype in that individual.48 Irrespective, a partial loss of GCC2 function is associated with a defect of LG movement and clinical presentation with NKD, suggesting an in vivo human relevance to killing efficiency and LG convergence. This evidence concerns the gene GCC2 and nervous system disorder.