Nectin-4 has been found to be overexpressed in various human cancers, including triple-negative breast cancer, ovarian cancer, lung cancer, pancreatic cancer, gastric cancer, melanoma, cutaneous squamous cell carcinoma oesophageal cancer, bladder cancer, urothelial cancer and head and neck squamous cell carcinoma (Bouleftour et al., 2022; Deng et al., 2019; Hashimoto et al., 2022; Heath and Rosenberg, 2021; Tanaka et al., 2021; Zhang et al., 2018). The gene discussed is NECTIN4; the disease is cancer.