This resilience may also, in part, be related to protective IGF-signalling as in vitro-derived OMNs, similarly to their in vivo counterpart, appear to have naturally high activation of PI3K-AKT signalling compared to spinal motor neurons, as shown through pAKT and β-catenin levels.5 AKT signalling may also promote survival by inhibiting p53, which induces cell death genes and is highly activated across ALS causations. This evidence concerns the gene IGF1 and amyotrophic lateral sclerosis.