SYT13 and amyotrophic lateral sclerosis: Human motor neurons were also protected in vitro across motor neuron disease toxicities and mutations, and while it is not clear how SYT13 works mechanistically, it was shown that the treatment reduced ER stress and apoptosis.8 RNA sequencing analysis of human post-mortem tissues of end-stage ALS patients, demonstrated that SYT13 levels were as high in remaining spinal motor neurons as in OMNs.