The CCHE score was created to predict covert HE (which comprises mHE and HE grade 1) in cirrhotic patients using variables such as serum albumin levels, clinically detectable ascites, a history of OHE, and scores from the simplified animal naming test and the activity subdomain of the Chronic Liver Disease Questionnaire (Labenz et al. 2019). This evidence concerns the gene ALB and hereditary elliptocytosis.