We identified HLA-E (q value = 7.91E−30) and ARF3 (q value = 2.48E−20); LAPTM5 (q value = 3.82E−23) and PLIN3 (q value = 9.21E−21); USP7 (q value = 3.68E−15) and SNRNP200 (q value = 6.14E−13) as top two ranked genes involved in isoform switching across baseline, discharge and 4–6 h post-seizure samples in comparison of PNES vs. Seizure groups, respectively (Supplementary Fig. 1). The gene discussed is HLA-E; the disease is Seizure.