P2RY1 and hemorrhagic disease: Ten of the consented subjects were diagnosed with bleeding disorders, which included VWD type 1, and 2M, MYH9-related disorder, thrombocytopenia suspected chronic ITP, severe hemophilia A with underlying alpha-thalassemia disease, acquired severe hemophilia A from systemic lupus erythematosus, mild hemophilia A, ADP receptor defect, and factor VII deficiency.