Nii-Kono et al. observed that uremic toxins hinder parathyroid hormone (PTH)-stimulated intracellular cyclic adenosine monophosphate production, decrease PTH receptor expression, and induce oxidative stress in osteoblast cells which induce adynamic bone disease (ABD) in patients with end-stage renal disease (ESRD) [4]. The gene discussed is PTH; the disease is stage 5 chronic kidney disease.